General Information

  • ID:  hor002521
  • Uniprot ID:  NA
  • Protein name:  Alyteserin-2Mb
  • Gene name:  NA
  • Organism:  Pseudis bolbodactyla
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ILGAIIPLVSGLLSHL
  • Length:  16
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T16 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Antimicrobial peptides
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002521_AF2.pdbhor002521_ESM.pdb

Physical Information

Mass: 188378 Formula: C77H134N18O19
Absent amino acids: CDEFKMNQRTWY Common amino acids: L
pI: 7.55 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 10
Hydrophobicity: 195.63 Boman Index: 3563
Half-Life: 20 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 219.38
Instability Index: 1430.63 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  22800568
  • Title:  Antimicrobial Peptides and Alytesin Are Co-Secreted From the Venom of the Midwife Toad, Alytes Maurus (Alytidae, Anura): Implications for the Evolution of Frog Skin Defensive Secretions